Wanted: Music recs!

So, I think I'm interested in widening my music library a little.  I'm having one of those days where iTunes looks like a big candy store, and I seriously have no idea where to start.  So far I've downloaded a little Alison Krauss, Matthew Perryman, and Jack Savoretti, so that might be indicative of what my ear seems to be craving right now:  clear vocals, a nice melody, and fairly mellow-sounding.  (I'd forgotten how much I LOVE Alison Krauss' voice. Gawd.)

Would y'all mind giving me a few artists to check out?  I'm really feeling like trying something new (or new to me, at least), so I'm curious to hear what my f-list is listening to or might recommend.  (Hit me up with your instrumental recs too.  Soundtracks, scores, the works!)